MAGIC BOOSTER

DESCRIPTION OF IBUTAMOREN (MK-677)
Ibutamoren (Also known as MK-677) is a potent, synthetic, long-acting, orally active, selective and non-peptide agonist of Ghrelin receptor, Ghrelin mimetic and growth hormone secretagogue. Ibutamoren has a chemical formula of C27H36N4O5S and a molar mass of 528.662 g/mol. The elimination half-life of ibutamoren is approximately 4-6 hours, but IGF-1 levels in humans remain high at a single oral dose for up to 24 hours.

Ibutamoren MK-677
EFFECT MECHANISM
Ibutamoren mimics the action of endogenous hormone Ghrelin in the body: Binds to Ghrelin receptors in the hypothalamus (Also known as Growth hormone secretagogue receptors), Stimulates the release of Growth hormone releasing hormone (GHRH), Increases GHRH signaling in GHRHs (Growth hormone free hormone receptors) in the pituitary gland, It inhibits the amount of Somatostatin (Growth hormone-inhibiting hormone; GHIH) and also suppresses Somatostatin activity by inhibiting Somatostatin receptor signaling. Thus, Ibutamoren stimulates Growth hormone secretion in all known ways to date, making it one of the most effective, strongest and most potent Growth hormone secretions ever known. The effect of Ibutamoren MK-677 causes a significant increase in plasma levels of GH (Growth hormone) and IGF-1 (Insulin-like growth factor 1) in the body without affecting cortisol and prolactin levels.

IBUTAMOREN, CLINICAL STUDIES AND POSSIBLE MEDICAL USE
Ibutamoren is being studied as a potential treatment for low levels of growth hormone and IGF-1, for example, in children or older adults with growth hormone deficiency (GHD). Human studies have shown the potent ability of ibutamoren to increase both muscle mass and bone mineral density, making it a promising potential therapy for the treatment of bone fragility in the elderly. According to some recent research, there is concern that its particularly longevity may over-stimulate ghrelin receptors in the brain and lead to harmful psychological side effects.
IBUTAMOREN PREVENTS MUSCLE WASTING, HAS AN ANTI-CATABOLIC EFFECT
In a clinical study of 8 food-deprived healthy volunteers, ibutamoren reversed protein loss that could cause muscle wasting. In 123 elderly patients with hip fractures, ibutamoren increased gait speed and muscle strength and decreased the number of falls. These studies have shown that ibutamoren has a great ability to prevent muscle wasting and potent anti-catabolic effects. Because of these abilities, ibutamoren is a promising candidate for the treatment of muscle wasting diseases (muscular dystrophy etc.).
SCIENTIFICALLY INVESTIGATED THE POSSIBLE BENEFITS OF IBUTAMOREN
Significantly increases IGF-1 serum levels and growth hormones
May be a promising treatment for growth hormone deficiency (GHD) and bone fragility in the elderly
Helps reduce excess body fat, stimulates triglyceride and oxidation breakdown in adipocytes
Promote lean muscle growth, improve performance and endurance
Has a strong anti-catabolic effect and the ability to preserve muscle mass / prevent muscle wasting
Supports general regeneration of the whole body (including internal organs), anti-aging effects
Helps increase calcium retention and increases bone density
May help heal wounds, bones, tendons and ligaments
May help reduce risk of heart and cardiovascular disease
May help boost the immune system
May help improve skin, nail and hair quality
Promotes a sense of energy and vitality
Improves sleep and quality
Nootropic effects, indirectly (by increasing IGF-1 – improving memory and learning; and increasing REM sleep duration and sleep quality – essential for cognitive functions)
IBUTAMOREN FAQ
What is Ibutamoren (MK-677)?
Ibutamoren (Also known as MK-677) is a potent, synthetic, long-acting, orally active, selective and non-peptide agonist of Ghrelin receptor, Ghrelin mimetic and growth hormone secretagogue.
What does ibutamoren do?
Ibutamoren mimics the action of the endogenous hormone Ghrelin in the body, stimulates the production of growth hormone by the pituitary and significantly increases plasma levels of GH (Growth hormone) and IGF-1 (Insulin-like growth factor 1).
Does ibutamoren have strong side effects?
In a scientific study, adult subjects also tolerated daily administration of MK-677 for a two-year period. The most common side effects are mild, transient, lower extremity edema, transient muscle pain, and increased appetite, which subsides within a few months.
What time of day should I buy the Mk 677?
Most users seem to prefer taking it at night, because ibutamoren improves sleep quality and increases the REM sleep duration phase.
Does ibutamoren MK-677 build muscle?
Yes, MK-677 (Ibutamoren) has been known to effectively increase human growth hormone as well as Insulin-like growth factor 1 (IGF-1). And both of these hormones play a very important role in building muscle mass and strength.
Is the MK 677 legal in the USA?
Because MK-677 is still an investigational new compound, it has not yet been approved for marketed for human consumption in the United States. However, it has been used experimentally in some bodybuilding community.
Is ibutamoren low testosterone?
Ibutamoren does not suppress testosterone levels. In fact, it has nothing to do with the primary and secondary genitalia.
Is Ibutamoren making you tired?
Ibutamoren may cause drowsiness. So taking it in the morning can make you feel sleepy throughout the day. For this reason, many people tend to take ibutamoren at night before sleep.
IBUTAMOREN DOSAGE
In scientific and clinical studies, the optimal dose of Ibutamoren MK-677 has been reported to be usually 20-30 mg once a day.
CONCLUSION
Ibutamoren is a potent, orally-active and selective Growth hormone secretion, significantly increases plasma levels of GH (Growth hormone) and IGF-1 (Insulin-like growth factor 1) in the body without affecting cortisol and prolactin levels. It could be a potential future treatment for children or older adults who are being treated for growth hormone deficiency (GHD) and bone fragility in the elderly. Ibutamoren is also a promising candidate for the treatment of muscle wasting diseases. In addition to scientific research, there have been numerous reports on various Internet forums about its other possible positive effects and benefits of ibutamoren. However, it is still an experimental compound that requires more intensive scientific and clinical research.

What is Alpha GPC?
Alpha GPC or alpha Glycerophosphocholine (AGPC), as its name suggests, is a choline-containing phospholipid isolated from soybeans.

What Does Alpha GPC Do?
There is a lot of research on this compound.

It supports the role of improving cognitive function, increasing strength,
Stimulating growth hormone release.
Alpha GPC contains a lipid chain that allows it to be taken up and incorporated into neuronal cell membranes.
The membrane-bound choline molecule provides the necessary and rate-limiting compound for acetylcholine neurotransmitter synthesis.
Although found in both the central and peripheral nervous systems. Cholinergic neurotransmission is the cornerstone of memory formation, which occurs in a special brain region known as the hippocampus.
What are the Benefits of Alpha Gpc?
Since the 1990s, animal models and human studies have shown many benefits of AGPC administration in human and animal studies. Here are some of the most notable benefits of Alpha Gpc:

Memory and Attention
Enhances Athletic Performance
Alpha GPC: Scientific Studies
One of the first human studies on AGPC attempted to replicate previous animal studies.

Memory and Attention
In the study, subjects were given either AGPC or a placebo for ten days and then given a powerful drug called scopolamine to induce temporary amnesia. This reduced scopolamine-induced memory impairments as measured by subjects performing memory and attention tasks. Since this study, agpc has been the focus of attention in age-related memory decline and other causes of memory impairment. One interesting study added AGPC to the widely recommended memory supplement most similar to Huperzine A (the AGPC component). It showed that the additional benefit was not just from the drug.

Increases Athletic Performance and Growth Hormone
Recent research on AGPC has shown that it has a potential benefit for athletic performance.

A Japanese study investigated the effects of a single dose of AGCP on hormone secretion in healthy young men. Surprisingly, a single dose of AGCP caused a significant change in growth hormone secretion within an hour. At 60 minutes, acute growth hormone levels were observed to increase by 290% over baseline levels. By the second hour, they had returned to baseline levels. At the same time, growth hormone was observed to increase fatty acid oxidation, as indicated by increases in free fatty acids and ketone bodies. The researchers hypothesized that the increase in circulating choline could temporarily block the negative feedback mechanism that regulates GH secretion. Short 6-day supplementation periods have been shown to directly increase endurance in college-aged athletes. A study conducted at the University of Louisiana used a crossover design to measure power produced during deadlifts and bench press-type movements. The study found a 3% improvement in lower-body strength with AGPC supplementation. The study suggested that a previous study on cholinergic transmission at neuromuscular junctions was a possible mechanism. However, no direct evidence has been found for the mechanism that provides better endurance.

Conclusion: Alpha GPC Scientific Studies
Cumulative evidence from animal models and human studies. Supports the role of AGPC as a well-tolerated cognitive enhancing compound with ergogenic properties. Soy lecithin isolate contains a phospholipid that allows it to be incorporated into neuronal cell membranes and used as a cholinergic neurotransmitter precursor. There was a transient increase in growth hormone associated with an increase in choline levels in the bloodstream. Even short-term supplementation with AGPC has been shown to benefit muscle strength.

Alpha Gpc Usage and Natural Sources
It is approximately 40% choline by weight, and therefore 1,000 mg of Alpha-GPC provides approximately 400 mg of choline. A standard Alpha-GPC dose based on the most common label doses is 300-600 mg. This dose follows a study using Alpha-GPC to increase power output (600 mg). And two studies have noted an increase in growth hormone secretion, which is probably a good dose for athletes. In the use of alpha-GPC for debilitating symptoms of cognitive decline, almost all studies use a dose of 1,200 mg per day. This is divided into three 400 mg doses. It is not clear how lower doses will benefit cognition. However, the dose that is consistently associated with benefit appears to be 1,200 mg.

Rat studies show that oral effects peak at 300-600 mg/kg, which is a human dose of 48-96 mg/kg (and 3,272-6,545 mg per day for a 150 lb human). For nootropic use, if you decide you would benefit more. We recommend starting with a dose of 300-600 mg and increasing from there. It is well tolerated when taken at the recommended doses. The acceptable dose range for most adults is relatively wide. Cumulative daily dose of 300-1200 mg when taken in one or two doses